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This gene encodes the cardiac isoform of troponin T. The encoded protein is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy.
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Serum Amyloid A (SAA) is an acute-phase protein The concentration of SAA in blood increases rapidly when tissue damage or inflammation occurs It is considered as an early biomarker for the diagnosis of many inflammatory diseases SAA can also be used as an important indicator of infection
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